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| Institution | Shares | Value | Change |
|---|---|---|---|
| FMR LLC | 6,059,574 | $353,697,322 | 0.00% |
| Avoro Capital Advisors LLC | 4,444,444 | $259,422,196 | 0.00% |
| RTW INVESTMENTS, LP | 4,424,968 | $258,285,382 | 0.00% |
| EcoR1 Capital, LLC | 3,988,971 | $232,836,237 | 0.00% |
| Aberdeen Group plc | 2,939,743 | $171,592,799 | 0.00% |
| FRANKLIN RESOURCES INC | 1,988,581 | $116,073,446 | 0.00% |
| BlackRock, Inc. | 1,446,099 | $84,408,799 | 0.00% |
| STATE STREET CORP | 1,444,010 | $84,286,864 | 0.00% |
| FRED ALGER MANAGEMENT, LLC | 1,290,391 | $75,320,123 | 0.00% |
| JPMORGAN CHASE & CO | 1,149,351 | $67,087,617 | 0.00% |
| JPMORGAN CHASE & CO | 1,149,351 | $67,087,617 | 0.00% |
| VANGUARD GROUP INC | 1,125,108 | $65,672,554 | 0.00% |
| 683 Capital Management, LLC | 1,070,000 | $62,455,900 | 0.00% |
| Nantahala Capital Management, LLC | 1,007,492 | $58,807,308 | 0.00% |
| JENNISON ASSOCIATES LLC | 999,484 | $58,339,880 | 0.00% |
| PRICE T ROWE ASSOCIATES INC /MD/ | 913,180 | $53,303 | 0.00% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 908,400 | $53,023,308 | 0.00% |
| TWO SIGMA INVESTMENTS, LP | 897,538 | $52,389,293 | 0.00% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 884,000 | $51,599,080 | 0.00% |
| Eversept Partners, LP | 877,373 | $51,212,262 | 0.00% |
| Institution | Action | Shares |
|---|---|---|
| LORD, ABBETT & CO. LLC | BUY | 176,025 |
| STATE OF WISCONSIN INVESTMENT BOARD | BUY | 3,568 |
| WESTFIELD CAPITAL MANAGEMENT CO LP | BUY | 3,828 |
| Burkehill Global Management, LP | BUY | 20,000 |
| Point72 Europe (London) LLP | BUY | 1,552 |
| Requisite Capital Management, LLC | BUY | 4,092 |
| Sigma Planning Corp | BUY | 4,500 |
| Atika Capital Management LLC | BUY | 90,000 |
| GAMMA Investing LLC | BUY | 4 |
| TD Asset Management Inc | BUY | 95,144 |
| BOONE CAPITAL MANAGEMENT LLC | BUY | 147,317 |
| Soleus Capital Management, L.P. | BUY | 200,000 |
| WINTON GROUP Ltd | BUY | 40,976 |
| Sassicaia Capital Advisers LLC | BUY | 16,000 |
| Darwin Global Management, Ltd. | BUY | 400,000 |
| T. Rowe Price Investment Management, Inc. | BUY | 977 |
| Cresset Asset Management, LLC | BUY | 6,087 |
| DNB ASSET MANAGEMENT AS | BUY | 11,802 |
| Palumbo Wealth Management LLC | BUY | 21,778 |
| TEMA ETFS LLC | BUY | 6,250 |
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